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Zetasizer Nano ZS (Malvern Instruments)

MANUFACTURER Malvern Instruments Limited (manufacturer's website)
MODEL Zetasizer Nano ZS
CONTACT 1 Linda Davies
CONTACT 2 Ken Madden
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SITE City Campus


The Zetasizer Nano ZS is a high performance two angle particle and molecular size analyzer for the enhanced detection of aggregates and measurement of small or dilute samples, and samples at very low or high concentration using dynamic light scattering with ‘NIBS’ optics. The ZSP also incorporates a zeta potential analyzer that uses electrophoretic light scattering for particles, molecules and surfaces, and a molecular weight analyzer using static light scattering.

Using Non-Invasive Backscatter optics (NIBS) it has significantly better performance than systems using 90 degree scattering optics.

In addition, a microrheology option is available for measuring sample viscosity and viscoelastic properties, as well as a Protein Measurement option for protein mobility measurements.

The flow mode option enables the system to be connected to an SEC or an FFF system to use as a detector for the size of proteins or nanoparticles.

A choice of cuvettes are available, from disposable single-use to specific cells for viscous or high concentration samples or measuring the zeta potential of surfaces.


Particle size and molecular size

  • Measurement range: 0.3nm – 10.0 microns (diameter)
  • Measurement principle:Dynamic Light Scattering
  • Minimum sample volume:12µL
  • Accuracy:Better than +/-2% on NIST traceable latex standards
  • Precision / Repeatability:Better than +/-2% on NIST traceable latex standards
  • Sensitivity:0.1mg/mL (Lysozyme)

Zeta potential (and optional Protein Mobility)

  • Measurement range: 3.8nm – 100 microns (diameter)
  • Measurement principle: Electrophoretic Light Scattering
  • Minimum sample volume: 150µL (20µL using diffusion barrier method)
  • Accuracy: 0.12µm.cm/V.s for aqueous systems using NIST SRM1980 standard reference material
  • Sensitivity:10mg/mL (BSA)

Molecular weight

  • Measurement range: 980Da – 20M Da
  • Measurement principle: Static Light Scattering using Debye plot
  • Minimum sample volume: 12µL (3-5 sample concentrations required)
  • Accuracy: +/- 10% typical

Microrheology (option)

  • Measurement principle: Dynamic Light Scattering
  • Minimum sample volume:12µL (DLS measurement only) maximum range, sample dependent


  • Temperature control range: 0°C - 90°C +/-0.1, 120ºC option
  • Light source: He-Ne laser 633nm, Max 4mW
  • Laser safety: Class 1
  • Power: 100VA at 25ºC

Weight and dimensions

  • Dimensions (W, D, H): 320mm, 600mm, 260mm (W,D,H)
  • Weight:21 kg

Operating environment

  • Temperature: 10°C – 35°C
  • Humidity: 35% - 80% non-condensing


  • Patents: The Zetasizer Nano range is protected by the following patents: Non-Invasive Back Scatter (NIBS) EP884580, US6016195, JP11051843 High and Low Frequency Electrophoreses (M3) EP1154266, US7217350, JP04727064 Light Scattering Measurements using Simultaneous Detection EP2235501, CN102066901, JP2011523451, US20090251696 Surface Potential Determination in a Dip Cell WO2012172330

Item ID #1480.

Last Updated: 21st August, 2017